If your sales, customers or your staff aren't firing on all cylinders.
Open up the bonnet. Get a mechanic to have a quick look. Tweak a few plugs, change the oil and filters. Replace any worn parts. Pump up the tyres. Give her a clean inside and out, put on the wax and give a good polish. Find a map with all the latest roads / highways listed. Mark down exactly where you are going. Check the fuel level and then, get back on the road.
PS - always remember to have something to eat yourself before setting off on long journeys.